tert-Butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate synthesis

1synthesis methods

Product Name:tert-Butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate
CAS Number:1323952-12-0
Molecular formula:C13H19ClN4O2
Molecular Weight:298.77

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57260-71-6 Synthesis

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tert-Butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate

1323952-12-0
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Yield:-

Reaction Conditions:

with potassium carbonate in 1-methyl-pyrrolidin-2-one at 90; for 1 h;

Steps:

1 Step 1: Tert-butyl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate

A solution of 2,5-dichloropyrimidine (19.4 g, 13.00 mmol, 1.05 equiv), tert-butyl piperazine-1-carboxylate (23 g, 12.40 mmol, 1 equiv), and K₂CO₃(34 g, 25.00 mmol, 2 equiv) in NMP (500 mL) was stirred for 1 h at 80° C. followed by the addition of 600 mL of H₂O which was added to the resulting solution. The solids were collected by filtration to afford 41 g crude of the title compound as a white solid. LCMS: [M+H]⁺299.13.

References:

US2019/330194,2019,A1 Location in patent:Paragraph 0570