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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide

1-[5-(4-AMino-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoroMethyl)phenyl]ethanone synthesis

8synthesis methods
5-BroMo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine

1337532-51-0
58 suppliers
$67.00/250mg

1-[5-(4-AMino-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoroMethyl)phenyl]ethanone

1337531-89-1
24 suppliers
$113.00/1mg

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Yield:-

Steps:

Multi-step reaction with 3 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium phosphate monohydrate; tri tert-butylphosphoniumtetrafluoroborate / 1,4-dioxane; water / 1.5 h / 85 °C / Inert atmosphere
2: hydrogenchloride / water; ethanol / 5 h / 85 °C / Inert atmosphere
3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

References:

Axten, Jeffrey M.;Medina, Jesús R.;Feng, Yanhong;Shu, Arthur;Romeril, Stuart P.;Grant, Seth W.;Li, William Hoi Hong;Heerding, Dirk A.;Minthorn, Elisabeth;Mencken, Thomas;Atkins, Charity;Liu, Qi;Rabindran, Sridhar;Kumar, Rakesh;Hong, Xuan;Goetz, Aaron;Stanley, Thomas;Taylor, J. David;Sigethy, Scott D.;Tomberlin, Ginger H.;Hassell, Annie M.;Kahler, Kirsten M.;Shewchuk, Lisa M.;Gampe, Robert T. [Journal of Medicinal Chemistry,2012,vol. 55,# 16,p. 7193 - 7207]

3680-69-1 Synthesis
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

3680-69-1
787 suppliers
$6.00/1g

1-[5-(4-AMino-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoroMethyl)phenyl]ethanone

1337531-89-1
24 suppliers
$113.00/1mg

References
22190-33-6 Synthesis
5-BROMOINDOLINE

22190-33-6
242 suppliers
$9.00/1g

1-[5-(4-AMino-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoroMethyl)phenyl]ethanone

1337531-89-1
24 suppliers
$113.00/1mg

References
5-(1-tert-Butyloxycarbonyl-2,3-dihydro-1H-indol-5-yl)-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine

1391053-27-2
14 suppliers
$800.00/500mg

1-[5-(4-AMino-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoroMethyl)phenyl]ethanone

1337531-89-1
24 suppliers
$113.00/1mg

References
tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate

837392-67-3
60 suppliers
$88.00/100mg

1-[5-(4-AMino-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoroMethyl)phenyl]ethanone

1337531-89-1
24 suppliers
$113.00/1mg

References