Tert-Butyl (((Meso-1R,5S,6S)-3-Benzyl-3-Azabicyclo[3.1.0]Hexan-6-Yl)Methyl)Carbamate synthesis
- Product Name:Tert-Butyl (((Meso-1R,5S,6S)-3-Benzyl-3-Azabicyclo[3.1.0]Hexan-6-Yl)Methyl)Carbamate
- CAS Number:134575-11-4
- Molecular formula:C18H26N2O2
- Molecular Weight:302.4113
24424-99-5
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![(3-benzyl-3-azabicyclo[3.1.0]hexan-6-yl)methanamine](/CAS/20200401/GIF/134575-10-3.gif)
134575-10-3
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134575-11-4
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Yield:134575-11-4 84%
Reaction Conditions:
with dmap in dichloromethane; for 16 h;
Steps:
B.4
Step 4: The crude amine (h) prepared in step 3 and N, N-dimethylaminopyridine (DMAP) (0.66 g, 5.4 mmol) were dissolved in CH2CI2(100ml_). To this solution was added di-tert-butyldicarbonate (7 g, 33 mmol), inportions, and the reaction mixture was stirred for 16 h. The reaction mixture wasthen washed two times (50 ml_) with water and once with brine (50 ml_). Theorganic phase was isolated and dried, and the solvent was removed underreduced pressure. The crude product was subjected to silica gel chromatographyusing 1:3 ethyl acetate:hexane as the eluting solvent. The eluted fractions werecombined and concentrated to yield 6.9 g of pure carbamate (i) (84%).
References:
WO2006/2133,2006,A1 Location in patent:Page/Page column 51-52
1631-26-1
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134575-11-4
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134575-08-9
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![exo-3-Benzyl-3-azabicyclo[3.1.0]hexane-6-methanol](/CAS2/GIF/134575-07-8.gif)
134575-07-8
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134575-11-4
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134575-06-7
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134575-11-4
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