N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine synthesis

4synthesis methods

Product Name:N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine
CAS Number:1353570-18-9
Molecular formula:C21H23FN6S
Molecular Weight:410.51

118430-73-2 Synthesis

118430-73-2
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N-(3-tert-butyl-1-Methyl-1H-pyrazol-5-yl)-4-(3-fluoro-4-(4-Methyl-1H-iMidazol-1-yl)phenyl)thiazol-2-aMine

1353570-18-9
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: acetone / 2 h / 60 °C / Inert atmosphere
2: potassium carbonate / methanol / 4 h / 25 °C / Inert atmosphere
3: ethanol / 18.25 h / 25 °C / Reflux; Inert atmosphere

References:

Rynearson, Kevin D.;Buckle, Ronald N.;Barnes, Keith D.;Herr, R. Jason;Mayhew, Nicholas J.;Paquette, William D.;Sakwa, Samuel A.;Nguyen, Phuong D.;Johnson, Graham;Tanzi, Rudolph E.;Wagner, Steven L. [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 16,p. 3928 - 3937]

369-33-5 Synthesis

369-33-5
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1353570-18-9
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References

1-(3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)ethan-1-one

1056050-42-0
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1353570-18-9
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References

59997-51-2 Synthesis

59997-51-2
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1353570-18-9
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References