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3',4'-Difluoroacetophenone

3',4'-Difluoroacetophenone Structure
3',4'-Difluoroacetophenone structure
CAS No.
369-33-5
Chemical Name:
3',4'-Difluoroacetophenone
Synonyms
1-(3,4-Difluorophenyl)ethan-1-one;4´3',4'-Difluoro;3',4'-Difluoroacetop;OTAVA-BB BB7020410077;3,4-DIFLUOROACETOPHENONE;3',4'-difluoroacetophenone;3,4-Difluoroacetophenone,98%;3',4'-Difluoroacetophenone99%;3',4'-Difluoroacetophenone>
CBNumber:
CB3130786
Molecular Formula:
C8H6F2O
Molecular Weight:
156.13
MDL Number:
MFCD00009891
MOL File:
369-33-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:57:21
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3',4'-Difluoroacetophenone Properties

Melting point 19-20 °C(lit.)
Boiling point 94-95 °C13 mm Hg(lit.)
Density 1.246 g/mL at 25 °C(lit.)
refractive index n20/D 1.4916(lit.)
Flash point 167 °F
storage temp. Sealed in dry,Room Temperature
form powder to lump to clear liquid
color White or Colorless to Light yellow
Specific Gravity 1.246
Water Solubility INSOLUBLE
BRN 2206856
InChI 1S/C8H6F2O/c1-5(11)6-2-3-7(9)8(10)4-6/h2-4H,1H3
InChIKey VWJSSJFLXRMYNV-UHFFFAOYSA-N
SMILES CC(=O)c1ccc(F)c(F)c1
CAS DataBase Reference 369-33-5(CAS DataBase Reference)
NIST Chemistry Reference 3',4'-Difluoroacetophenone(369-33-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29147000
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

3',4'-Difluoroacetophenone price More Price(70)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 264288 3′,4′-Difluoroacetophenone 97% 369-33-5 5g $61.6 2026-04-30 Buy
TCI Chemical D1906 3',4'-Difluoroacetophenone >97.0%(GC) 369-33-5 5g $22 2026-04-30 Buy
TCI Chemical D1906 3',4'-Difluoroacetophenone >97.0%(GC) 369-33-5 25g $62 2026-04-30 Buy
Usbiological 273548 3',4'-Difluoroacetophenone Asreported 369-33-5 50g $360 2026-06-03 Buy
Usbiological 273548 3',4'-Difluoroacetophenone Asreported 369-33-5 100g $499 2026-06-03 Buy
Product number Packaging Price Buy
264288 5g $61.6 Buy
D1906 5g $22 Buy
D1906 25g $62 Buy
273548 50g $360 Buy
273548 100g $499 Buy

3',4'-Difluoroacetophenone Chemical Properties, Uses, Production

Chemical Properties

clear yellowish liquid after melting

Uses

3′,4′-Difluoroacetophenone may be used in chemical synthesis.

Definition

ChEBI: 1-(3,4-Difluorophenyl)ethan-1-one is an aromatic ketone.

Synthesis

1,2-Difluorobenzene

367-11-3

Acetyl chloride

75-36-5

3',4'-Difluoroacetophenone

369-33-5

Anhydrous aluminum trichloride (117 g) was slowly added to a mixed solution of 1,2-difluorobenzene (50 g) with acetyl chloride (86 g) at room temperature. The formed slurry was heated to 30°C with continuous stirring. Upon completion of the reaction, the red reaction mixture was cooled to 20 °C and subsequently slowly poured into 800 g of ice-water mixture with continued stirring for 30 min. The organic phase was separated and the aqueous phase was extracted with dichloromethane (3 x 500 ml). All organic phases were combined and washed sequentially with water (2 x 500 ml), saturated sodium bicarbonate solution (2 x 500 ml) and 15% brine (2 x 500 ml), followed by drying with anhydrous sodium sulfate. The organic phases were concentrated to remove the solvent and finally distilled under reduced pressure to collect the fractions at 95 °C/13 mmHg to give 3',4'-difluoroacetophenone (51 g).

References

[1] Journal of Fluorine Chemistry, 1980, vol. 15, p. 245 - 252
[2] Journal of the Indian Chemical Society, 1982, vol. 59, # 2, p. 293 - 294
[3] Heterocycles, 1981, vol. 16, # 9, p. 1545 - 1553
[4] Journal of Medicinal Chemistry, 1979, vol. 22, # 11, p. 1385 - 1389
[5] Heterocycles, 1981, vol. 16, # 1, p. 71 - 76

3',4'-Difluoroacetophenone Preparation Products And Raw materials

Raw materials

1,2-Difluorobenzene Acetyl chloride

Preparation Products

2-Amino-4-(3,4-difluorophenyl)thiazole Methyl 3,4-difluorobenzoate 2-Propen-1-one, 1-(3,4-difluorophenyl)-3-(dimethylamino)-, (2E)-

3',4'-Difluoroacetophenone Suppliers

Global Suppliers ( 320)
Supplier Tel Email Country ProdList Advantage
Guangzhou Co-integrity Pharmaceutical Technology Co., Ltd. 13660719760 3533514074@qq.com China 105 58
Hubei Yihua New Materials Technology Co., Ltd. 17754433341 18086038039 986173822@qq.com China 946 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 45000 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Guangzhou Co-integrity Pharmaceutical Technology Co., Ltd. 58
Hubei Yihua New Materials Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Liaoning Tianhua Chemical Co., Ltd. 69
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 3',4'-Difluoroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3′, 4′-Difluoroacetophenone pictures 2026-05-28 3′, 4′-Difluoroacetophenone
369-33-5
 $9.50 1KG 99% 100ton Hebei Chuanghai Biotechnology Co,.LTD
3',4'-Difluoroacetophenone pictures 2022-02-19 3',4'-Difluoroacetophenone
369-33-5
 1KG 97.6% 100 tons Honest Joy Holdings Limited
3',4'-Difluoroacetophenone pictures 2019-12-20 3',4'-Difluoroacetophenone
369-33-5
 $1.00 1KG 99% Career Henan Chemical Co

3',4'-Difluoroacetophenone Spectrum

3',4'-Difluoroacetophenone(369-33-5)MS3',4'-Difluoroacetophenone(369-33-5)1HNMR3',4'-Difluoroacetophenone(369-33-5)13CNMR3',4'-Difluoroacetophenone(369-33-5)IR13',4'-Difluoroacetophenone(369-33-5)Raman

369-33-5 (3',4'-Difluoroacetophenone ) Related Search:

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1-(3,4-DIFLUORO-PHENYL)-ETHANONE 3,4-DIFLUOROACETOPHENONE OTAVA-BB BB7020410077 Ethanone, 1-(3,4-difluorophenyl)- 3,4-Difluoroacetophenone,98% 3',4'-Difluoro 3',4'-Difluoroacetophenone 99% 3',4'-Difluoroacetophenone99% 3,4-Difluorophenyl(methyl) ketone 3',4'-Difluoroacetop 4´ 3,4-Difluoroacetophenone≥ 98% (GC) 3',4'-Difluoroacetophenone> 3',4'-difluoroacetophenone 3′,4′-Difluoroacetophenone, CAS 369-33-5 1-(3,4-Difluorophenyl)ethan-1-one 369-33-5 69-33-5 KETONE Organic Building Blocks Ketones C7 to C8 Carbonyl Compounds Building Blocks Acetophenone Series Aromatic Acetophenones & Derivatives (substituted) ketone Miscellaneous Adehydes, Acetals & Ketones Fluorine Compounds C7 to C8 Carbonyl Compounds Ketones bc0001