[1-(3-Methoxy-4-nitro-phenyl)-piperidin-4-yl]-carbaMic acid tert-butyl ester synthesis

Yield: 71.2%

Reaction Conditions:

with potassium carbonate in acetonitrile for 3 h;Inert atmosphere;

Steps:

1.1 Step 1 Synthesis of Compound 3
Add compound 1 to a 50 mL single-mouth flask equipped with magnetic stirring(1.71 g, 10 mmol) and acetonitrile(30 mL), stirred and dissolved, and added compound 2 (2.6 g, 13 mmol)And potassium carbonate (2.07g, 15mmol),The reaction mixture was heated to 70 ° C under a nitrogen atmosphere and stirred for 3 hours while stirring.Cool to room temperature, distill off the solvent under reduced pressure and add water (60 mL).A large amount of yellow solid was precipitated, filtered, washed with water (10 mL).Drying the yellow solid2.5g,The yield was 71.2%.

References:

Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.;Wang Yihan;Li Huanyin CN109851638, 2019, A Location in patent:Paragraph 0215-0220