1,4-Heptadien-3-one, 7,7,7-trifluoro-5-hydroxy-1-methoxy-6,6-dimethyl- synthesis
- Product Name:1,4-Heptadien-3-one, 7,7,7-trifluoro-5-hydroxy-1-methoxy-6,6-dimethyl-
- CAS Number:1357476-62-0
- Molecular formula:C10H13F3O3
- Molecular Weight:238.2
4652-27-1
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Yield:-
Reaction Conditions:
with lithium hexamethyldisilazane in tetrahydrofuran at -78 - 20;
Steps:
Step 2: Synthesis of compound D3-3
To a solution of 4-methoxy-3-buten-2-one (642 g) in anhydrous THF(16 L), 6.42 L LiHMDS(1 mol/L) dissolved in THF was added dropwise at -78°C. After stirred at -78°C for 2 h, suspension in step 1 dissolved in THF(1 L) was added to the reaction system slowly, stirred at -78°C for 1-2 h, the reaction mixture was heated to room temperature and stirred for 16 h. The resulting reaction mixture was used in the next step directly. (0192) LC-MS [M+H]+ : 239.
References:
EP4056575,2022,A1 Location in patent:Paragraph 0189; 0191-0192
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