4 - boric acid pinacol ester - 9, 9 - dimethyl fluorene synthesis
- Product Name:4 - boric acid pinacol ester - 9, 9 - dimethyl fluorene
- CAS Number:1365692-79-0
- Molecular formula:C21H25BO2
- Molecular Weight:320.23
942615-32-9
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$11.00/250mg
25015-63-8
224 suppliers
$22.39/5G
1365692-79-0
77 suppliers
$45.00/2.5mg
Yield:1365692-79-0 90.3%
Reaction Conditions:
with triethylamine;1,3-bis[(diphenylphosphino)propane]dichloronickel(II) in toluene at 80; for 8 h;Inert atmosphere;
Steps:
1.b-3
In a 300-ml three-neck flask, 7.0 g (26.0 mmol) of the compound b-1, 7.57 ml (52.0 mmol) of the compound b-2, 100 ml of toluene, and 20 ml of triethylamine were charged, and 1.4 g of [1, 1 ' -bis (diphenylphosphino) propane] dichloro nickel was added at room temperature in a nitrogenatmosphere under stirring condition. The temperature was increased to 80°C, and stirring was performed for 8 hours. After the reaction, an organic layer was extracted with toluene, was then dried using anhydrous sodium sulfate, and was subsequently refined using a silica gel column (mixture of toluene and heptane: developing solvent), so that 7.45 g of the compound b-3 (white oil) (yield: 90.3%) was obtained.
References:
WO2012/35962,2012,A1 Location in patent:Page/Page column 37; 38
942615-32-9
165 suppliers
$11.00/250mg
73183-34-3
593 suppliers
$6.00/5g
1365692-79-0
77 suppliers
$45.00/2.5mg