ChemicalBook CAS DataBase List (2,7-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-9,9-DIOCTYLFLUORENE)

(2,7-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-9,9-DIOCTYLFLUORENE) synthesis

9synthesis methods

Product Name:(2,7-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-9,9-DIOCTYLFLUORENE)
CAS Number:196207-58-6
Molecular formula:C41H64B2O4
Molecular Weight:642.57

61676-62-8 Synthesis

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

61676-62-8
310 suppliers
$10.00/5g

198964-46-4
186 suppliers
$16.00/5g

(2,7-BIS(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-9,9-DIOCTYLFLUORENE)

196207-58-6
163 suppliers
$37.50/250 mg

Yield:196207-58-6 80%

Reaction Conditions:

Stage #1:2,7-dibromo-9,9-dioctylfluorene with n-butyllithium in tetrahydrofuran;hexane at -78; for 2 h;Inert atmosphere;
Stage #2:2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran;hexane at 20; for 20 h;Inert atmosphere;

Steps:

3 Example 3
Preparation of 2,7-bis (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -9,9-dioctylfluorene (M-2)
Under argon protection,In a 500 mL long three-necked flask,Was added 2,7-dibromo-9,9-dioctylfluorene (21.9 g, 40 mmol)And 250 mL of anhydrous tetrahydrofuran,The reaction solution was cooled to -78 ° C with liquid nitrogen,A n-hexane solution of n-butyllithium (48 mL, 2.5 M, 120 mmol) was slowly added dropwise,After stirring at -78 ° C for 2 hours,2-isopropyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (26 g, 140 mmol) was injected in one portion,Let it naturally rise to room temperature,Continue to react for 20 h.The reaction mixture was poured into water and extracted with methylene chloride. The mixture was washed five times. The organic phase was separated, dried, filtered and the solvent was dried. The residue was purified by column chromatography. The crude product was purified by silica gel as a stationary phase and petroleum ether / dichloromethane as the mobile phase. After purification, 43.8 g of a white solid was obtained in 80% yield.

References:

South China University of Technology;Guo Ting;Fu Denghao;Ying Lei;Yang Wei;Peng Junbiao;Cao Yong CN106588869, 2017, A Location in patent:Paragraph 0053; 0054; 0055; 0056

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