2-Chloro-N-[1,2,4]triazol-4-yl-acetaMide, 98+% C4H5ClN4O, MW: 160.56 synthesis

Yield:137141-14-1 80.76%

Reaction Conditions:

with triethylamine in ethanol; for 0.3 h;Microwave irradiation;

Steps:

General procedure for synthesis of differentsubstituted acylamino-1,2,4-triazoles (11-20)

General procedure: Microwave method Acid chloride (0.01 mol) was taken in a 50 ml beaker andwas dissolved in a minimum quantity of ethanol. 4-Amino-1,2,4-triazole (0.01 mol, 0.84 g) was added to it and wasmixed with the help of a glass rod. After this dropwise addtriethylamine (0.01 mol, 1.01 g) to it. It was then irradiatedin microwave oven at 360 W. Completion of reactionwas monitored by TLC at an interval of 2 min. After the completion of reaction, the mixture was cooled to roomtemperature and the product was recrystallized from ethanolto furnish amide.

References:

Kaur, Gurinderjit;Kaur, Harleen;Kaur, Pardeep;Sharma, Sunita;Singh, Ravneet [Indian Journal of Heterocyclic Chemistry,2021,vol. 31,# 3,p. 389 - 395]