2-(4-fluorophenyl)-8,8-dimethyl-7,8-dihydroimidazo[1,2-a]pyrazin-6(5H)-one synthesis
- Product Name:2-(4-fluorophenyl)-8,8-dimethyl-7,8-dihydroimidazo[1,2-a]pyrazin-6(5H)-one
- CAS Number:1374414-03-5
- Molecular formula:C14H18O4
- Molecular Weight:250.29
Yield:1374414-03-5 30%
Reaction Conditions:
with potassium carbonate in acetone at 60; for 3 h;
Steps:
1.2 Step 2: Preparation of (E)-methyl 3-(3-methoxy-4-propoxyphenyl)acrylate
After dissolving 0.5 g (2.4 mmol) of methyl ferulate prepared in step 1 in 6 ml of dry acetone, 0.4 g (2.9 mmol) of anhydrous K2CO3 was added. After adding 0.26 ml (2.6 mmol) of 1-iodopropane, the mixture was heated and stirred at 60° C. for 3 hours. The mixture was cooled, extracted with diethyl ether, dried over MgSO4, and concentrated under reduced pressure. Purification by column chromatography (hexane: ethyl acetate = 1:1) was carried out to obtain (E)-methyl 3-(3-methoxy-4-propoxyphenyl)acrylate. Light yellow solid (30%);
References:
KR101599525,2016,B1 Location in patent:Paragraph 0166-0167; 0171-0176
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