tert-butyl 2-(3-iodo-5-methyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate synthesis
- Product Name:tert-butyl 2-(3-iodo-5-methyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate
- CAS Number:1386457-83-5
- Molecular formula:C13H16IN3O2
- Molecular Weight:373.19
5292-43-3
444 suppliers
$10.00/5g
![3-iodo-5-methyl-1H-Pyrazolo[3,4-c]pyridine](/CAS/20180629/GIF/1386457-82-4.gif)
1386457-82-4
14 suppliers
inquiry
1386457-83-5
9 suppliers
inquiry
Yield:-
Reaction Conditions:
with potassium carbonate in acetonitrile at 20; for 16 h;Reflux;
Steps:
B
To a suspension of 3-iodo-5-methyl-1 H-pyrazolo[3,4-c]pyridine (1.00 g, 3.86 mmol), and potassium carbonate (1.28 g, 9.26 mmol) in acetonitrile (40 ml_) was added tert-butyl bromoacetate (0.685 ml_, 4.63 mmol) dropwise at RT and the resulting mixture was heated to reflux for 16 h. The mixture was cooled to RT and filtered, the solid was washed with acetonitrile and the filtrate was concentrated under vacuum. The residual oil was used directly in the next step without further purification. MS (LC/MS): 374.0 [M+H]+; tR (HPLC conditions k): 2.96 min.
References:
WO2012/93101,2012,A1 Location in patent:Page/Page column 157-158
![5-METHYL-1H-PYRAZOLO[3,4-C]PYRIDINE](/CAS/GIF/76006-06-9.gif)
76006-06-9
53 suppliers
$65.00/50mg
1386457-83-5
9 suppliers
inquiry