3-(aminocarbonyl)-5-methyl-1H-Pyrazolo[3,4-c]pyridine-1-acetic acid synthesis
- Product Name:3-(aminocarbonyl)-5-methyl-1H-Pyrazolo[3,4-c]pyridine-1-acetic acid
- CAS Number:1386457-85-7
- Molecular formula:C10H10N4O3
- Molecular Weight:234.21
![tert-butyl 2-(3-cyano-5-methyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate](/CAS/20180808/GIF/1386457-84-6.gif)
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Yield:-
Reaction Conditions:
with trifluoroacetic acid at 140; for 1.5 h;microwave irradiation;
Steps:
D
A solution of tert-butyl 2-(3-cyano-5-methyl-1 H-pyrazolo[3,4-c]pyridin-1-yl)acetate (250 mg, 0.92 mmol) in TFA (4 mL) was subjected to microwave irradiation at 140°C for 90 min. The reaction mixture was concentrated in vacuo, the residual solid was suspended in methanol and concentrated again in vacuo. MS: 235.0 [M+H]+; tR (HPLC conditions k): 0.24 min.
References:
WO2012/93101,2012,A1 Location in patent:Page/Page column 157-158
![5-METHYL-1H-PYRAZOLO[3,4-C]PYRIDINE](/CAS/GIF/76006-06-9.gif)
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![3-iodo-5-methyl-1H-Pyrazolo[3,4-c]pyridine](/CAS/20180629/GIF/1386457-82-4.gif)
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![tert-butyl 2-(3-iodo-5-methyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetate](/CAS/20180703/GIF/1386457-83-5.gif)
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