ChemicalBook CAS DataBase List Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate synthesis

11synthesis methods

Product Name:Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
CAS Number:139481-69-9
Molecular formula:C25H22N6O3
Molecular Weight:454.48

Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate

139481-44-0

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate

139481-69-9

1. Methyl 2-ethoxy-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole-7-carboxylate (310 g) and toluene (2.48 L) were added to a reactor, followed by tributyltin chloride (737 g), sodium azide (146 g) and tetrabutylammonium bromide (31 g). 2. The reaction mixture was slowly heated to 110 °C and maintained at 110-115 °C for 24 h, during which the progress of the reaction was monitored by TLC. 3. After completion of the reaction, the reaction mixture was cooled to 15 °C and methanol (3.1 L), water (2.17 L) and acetic acid (930 g) were added sequentially. 4. The mixture was stirred at 15-20 °C for 1 h to promote product separation. 5. After addition of toluene (1.24 L), the reaction mixture was filtered at 15-20 °C. 6. the filter cake was washed thoroughly with water (0.93 L) until the pH of the wash solution reached 5.5-7.0 to completely remove the acid. 7. The filter cake was washed again with toluene (0.62 L) and dried by suction filtration. 8. The product was air dried at 50-55 °C to give methyl 2-ethoxy-1-[[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole]-7-carboxylate. Yield: 290 g (85%).

21606-04-2 Synthesis

21606-04-2
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$7.00/1g

139481-69-9
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$8.00/250mg

Yield:-

Steps:

Multi-step reaction with 8 steps
1: SOCl₂, DMF / toluene / 0.5 h / Heating
2: NaN₃ / acetone; H₂O / 1 h
3: 1.5 h / Heating
4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating
5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
7: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
8: 100 percent / trimethyltin azide / toluene / 29 h / Heating

References:

Kubo, Keiji;Kohara, Yasuhisa;Imamiya, Eiko;Sugiura, Yoshihiro;Inada, Yoshiyuki;et al. [Journal of Medicinal Chemistry,1993,vol. 36,# 15,p. 2182 - 2195]

139481-44-0 Synthesis

139481-44-0
329 suppliers
$9.00/5g

139481-69-9
151 suppliers
$8.00/250mg

References