Ethyl 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate oxalate synthesis
- Product Name:Ethyl 2-(((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate oxalate
- CAS Number:1402149-98-7
- Molecular formula:C14H23NO9
- Molecular Weight:349.34
Yield: 98%
Reaction Conditions:
in ethanol
Steps:
1.5 (5) Synthesis of Compound VI
35.8 g of Compound V product (0.14 mol, 1 eq), 300 mL of ethanol was added to the reaction flask, stirred and dissolved, and then an ethanolic solution of oxalic acid (13.7 g / 100 mL of ethanol, 0.15 mol, 1.1 eq) was added dropwise; Part of the ethanol was distilled off under reduced pressure and suction filtered to give a crude material. The crude product was placed in 300 mL of acetone, heated and beaten, cooled to room temperature, suction filtered, rinsed with acetone, and dried to give 47.3 g of white solid product, Compound VI, yield 98%.
References:
Nantong Changyou Pharmaceutical Technology Co., Ltd.;Li Zebiao;Xiao Jianxi;Zhang Qinghai;Zhang Lei;Cao Hong;Lin Yanfeng CN108084145, 2018, A Location in patent:Paragraph 0019
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