4,4,5,5-Tetramethyl-2-[4-(oxan-4-yloxy)phenyl]-1,3,2-dioxaborolane synthesis
- Product Name:4,4,5,5-Tetramethyl-2-[4-(oxan-4-yloxy)phenyl]-1,3,2-dioxaborolane
- CAS Number:1416157-80-6
- Molecular formula:C17H25BO4
- Molecular Weight:304.19
215453-84-2
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73183-34-3
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Yield:1416157-80-6 77%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in N,N-dimethyl-formamide at 125; for 5 h;Inert atmosphere;
Steps:
A General Method E (Borylation of aryl halides): using B^pm? / Pd
General procedure: A mixture of aryliodide or arylbromide (1 equiv.), bis(pinacolato)diboron (1.2 to 1.5 equiv.), OAc (3 equiv.) and DMF or DMSO was purged with Ar for 10 min. [1,1'- PdCl2dppf*CH2Cl2 (3-5 mol%) was added, the vial sealed and heated at 85-100 °C for 2-3 h. The product was partitioned between EtOAc and satd aq NaHC03 solution, washed with brine, dried over Na2S04 or MgS0 , filtered, and concentrated to dryness. The crude product was purified by flash chromatography to give the title compound.
References:
WO2013/53051,2013,A1 Location in patent:Page/Page column 68; 81
97986-34-0
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269409-70-3
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1416157-80-6
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2081-44-9
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![2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE](/CAS/GIF/68716-49-4.gif)
68716-49-4
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2081-44-9
293 suppliers
$6.00/1g
1416157-80-6
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