2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE synthesis
- Product Name:2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE
- CAS Number:68716-49-4
- Molecular formula:C12H16BBrO2
- Molecular Weight:282.97
76-09-5
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68716-49-4
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Yield:68716-49-4 99.7%
Reaction Conditions:
in acetonitrile at 20; for 1.5 h;
Steps:
2
A suspension of commercially available 4-bromoplienyl boronic acid (18, 253.0 g, 1.24 mol) in acetonitrile (1000 ml) was stirred at room temperature. Pinacol (150.9g, 1.27 mol) was added and stirring was continued 1.5 h until a clear solution was obtained. The solvent was removed at 30°-35°C under vacuum to give crude 4- bromo-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)benzene (20, 349.9g, 99.7% yield) as light yellow solid. (1H NMR (300 MHz, CDCl3) δ 7.66 (d, J= 8.4 Hz, 2H), 7.50 (d, J= 8.4 Hz, 2Hz), 1.34 (s, 12H) ppm).
References:
WO2006/122117,2006,A2 Location in patent:Page/Page column 23
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68716-49-4
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