ChemicalBook CAS DataBase List (2-Butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone

(2-Butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone synthesis

12synthesis methods

Product Name:(2-Butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone
CAS Number:141645-23-0
Molecular formula:C30H40N2O5
Molecular Weight:508.65

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(2-Butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone

141645-23-0
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: triphenylphosphine / dichloromethane / 1 h / 40 °C / Inert atmosphere
1.2: 3 h / 110 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere
3.1: aluminum (III) chloride / chlorobenzene / 2 h / 80 °C / Inert atmosphere
4.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 5 h / 65 °C / Inert atmosphere

References:

Chen, Hao;Chen, Xiuhui;Hu, Wenhui;Hua, Lei;Li, Xinxuan;Pan, Jintao;Sun, Ping;Wu, Dan;Wu, Xinyi;Yang, Zhongjin;Yue, Hu;Zhang, Cheng [Bioorganic and Medicinal Chemistry Letters,2021,vol. 46]