3-Methyl-5-(trimethylsilyl)isoxazole-4-boronic Acid Pinacol Ester synthesis
- Product Name:3-Methyl-5-(trimethylsilyl)isoxazole-4-boronic Acid Pinacol Ester
- CAS Number:1429913-32-5
- Molecular formula:C13H24BNO3Si
- Molecular Weight:281.23
683-58-9
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Yield:1429913-32-5 92%
Reaction Conditions:
with potassium hydrogencarbonate in 1,2-dimethoxyethane at 50; for 16 h;
Steps:
8
A suspension of compound 20 (1 g, 4.5 mmol, 1.0 eq), compound 18 (421.2 mg, 4.5 mmol, 1.01 eq) and KHC03 (893.1 mg, 8.9 mmol, 2.00 eq) in DM E (20 mL) was heated at 50 °C for 16 h. After cooling to room temperature, the reaction mixture was filtered and concentrated under vacuum. The residue was purified by column chromatography (0.5-2% EtOAc in PE) to afford compound 21 (1.3 g, 4,1 mmol, 92% yield, 91.9% purity) as a white solid: H NMR (300 MHz, CDCI3) δ 0.28 - 0.35 (s, 9H) 1.22 - 1.30 (s, 12H) 2.32 (s, 3H);ES m/z 282.3[M + 1]+.
References:
WO2016/97870,2016,A1 Location in patent:Page/Page column 0175
51451-05-9
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159087-46-4
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$56.00/100mg
1429913-32-5
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61676-62-8
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$11.19/5G
1066-54-2
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1429913-32-5
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1066-54-2
477 suppliers
$9.00/10g
1429913-32-5
16 suppliers
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61676-62-8
329 suppliers
$11.19/5G
1429913-32-5
16 suppliers
inquiry