(R,S)-Z-3-AMINO-5-CYCLOHEXYL-2-OXO-1,4-BENZODIAZEPINE synthesis
- Product Name:(R,S)-Z-3-AMINO-5-CYCLOHEXYL-2-OXO-1,4-BENZODIAZEPINE
- CAS Number:146373-94-6
- Molecular formula:C23H25N3O3
- Molecular Weight:391.46
![Carbamic acid, N-[1-(1H-benzotriazol-1-yl)-2-[[2-(cyclohexylcarbonyl)phenyl]amino]-2-oxoethyl]-, phenylmethyl ester](/CAS/20210305/GIF/951220-93-2.gif)
951220-93-2
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146373-94-6
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Yield:146373-94-6 410 mg
Reaction Conditions:
Stage #1: [benzotriazol-1-yl-(2-cyclohexanecarbonyl-phenylcarbamoyl)-methyl]-carbamic acid benzyl esterwith ammonia in tetrahydrofuran;methanol; for 18 h;
Stage #2: with ammonium acetate;acetic acid at 20; for 18 h;
References:
Carter, Malcolm C.;Alber, Dagmar G.;Baxter, Robert C.;Bithell, Sian K.;Budworth, Jo;Chubb, Ann;Cockerill, G. Stuart;Dowdell, Verity C. L.;Henderson, Elisa A.;Keegan, Sally J.;Kelsey, Richard D.;Lockyer, Michael J.;Stables, Jeremy N.;Wilson, Lara J.;Powell, Kenneth L. [Journal of Medicinal Chemistry,2006,vol. 49,# 7,p. 2311 - 2319]
![N-[2-(cyclohexylcarbonyl)phenyl]Acetamide](/CAS/20180702/GIF/146373-93-5.gif)
146373-93-5
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146373-94-6
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525-76-8
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146373-94-6
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621-84-1
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$7.00/25g
146373-94-6
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3432-87-9
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146373-94-6
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$160.00/250mg