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15-(4-IODOPHENYL)PENTADECANOIC ACID synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 94 percent / diethyl ether / 12 h / 0 °C
2: 1.) Tl(OCOCF3)3, 2.) aq. KI / 1.) TFA, RT, 5 d, 2.) TFA, 15 min
3: 90 percent / 1 N NaOH / ethanol / 1.5 h / Heating

References:

Goodman, M. M.;Kirsch, G.;Knapp, F. F. [Journal of Medicinal Chemistry,1984,vol. 27,# 3,p. 390 - 397]

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