2,3,4,9-TETRAHYDROSPIRO[OXETANE-3,1-PYRIDO[3,4-B]INDOLE] synthesis

Yield:1523558-63-5 75%

Reaction Conditions:

in acetonitrile at 82; for 18 h;Inert atmosphere;Pictet-Spengler Synthesis;Solvent;Reagent/catalyst;Temperature;

Steps:

General Method A

General procedure: To a stirred solution of the oxetan-3-one (1 equiv.) in acetonitrile (5 mL) wasadded under an atmosphere of anhydrous nitrogen the amine (1.2 equiv.) and the mixture stirred atreflux for 18 h. After cooling to room temperature, the solvent was removed in vacuo. Purificationwas achieved by silica gel column chromatography

References:

Beasley, Benjamin O.;Alli-Balogun, Abimbola;Clarkson, Guy J.;Shipman, Michael [Tetrahedron Letters,2014,vol. 55,# 2,p. 541 - 543] Location in patent:supporting information