ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE synthesis
- Product Name:ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE
- CAS Number:153597-59-2
- Molecular formula:C9H12N2O3
- Molecular Weight:196.2
85230-37-1
90 suppliers
$58.00/1g
109-64-8
495 suppliers
$10.00/5g
153597-59-2
44 suppliers
$55.00/100mg
Yield:153597-59-2 96%
Reaction Conditions:
with potassium carbonate in acetonitrile; for 16 h;Reflux;
Steps:
13.1 Step 1
The compound ethyl 5-hydroxy-1H-pyrazole-3-carboxylate (1.0g, 6.40mmol), 1,3-dibromopropane (0.72mL, 7.04mmol) and potassium carbonate (3.54g, 25.65 mmol) was added to acetonitrile (40 mL) and heated to reflux for 16 hours. After the raw material reaction is complete, the reaction solution is cooled to room temperature, filtered to remove insoluble materials, and the filtrate is concentrated to obtain the crude oily product 6,7-dihydro-5H-pyrazolo[5,1-b][1,3] Ethyl oxazine-2-carboxylate (1.81 g, Y: 96%).
References:
CN113429410,2021,A Location in patent:Paragraph 0312-0314
109-64-8
495 suppliers
$10.00/5g
85230-37-1
90 suppliers
$58.00/1g
153597-59-2
44 suppliers
$55.00/100mg