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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE
158985-37-6

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE synthesis

3synthesis methods
1-Boc-4-(4-methoxycarbonylphenyl)piperazine

158985-36-5
71 suppliers
$25.00/250mg

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

158985-37-6
59 suppliers
$42.00/250mg

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Yield:158985-37-6 98%

Reaction Conditions:

Stage #1: 4-(4-methoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl esterwith diethylzinc;lithium chloride in tetrahydrofuran;hexane at 20; for 6 h;Inert atmosphere;
Stage #2: with sodium hydroxide in tetrahydrofuran;hexane;water at 20; for 8 h;Inert atmosphere;chemoselective reaction;

References:

Kovalenko, Oleksandr O.;Adolfsson, Hans [Chemistry - A European Journal,2015,vol. 21,# 7,p. 2785 - 2788] Location in patent:supporting information

4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid

162046-66-4
144 suppliers
$6.00/250mg

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

158985-37-6
59 suppliers
$42.00/250mg

References
1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE

197638-83-8
108 suppliers
$7.00/250mg

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

158985-37-6
59 suppliers
$42.00/250mg

References

TERT-BUTYL 4-[4-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE Related Search:

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Sulfanilamide TERT-BUTYL 4-[2-(HYDROXYMETHYL)PHENYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE