4(3H)-Pyrimidinone, 5-bromo-6-(difluoromethyl)-3-[(4-methoxyphenyl)methyl]- synthesis
- Product Name:4(3H)-Pyrimidinone, 5-bromo-6-(difluoromethyl)-3-[(4-methoxyphenyl)methyl]-
- CAS Number:1591828-80-6
- Molecular formula:C13H11BrF2N2O2
- Molecular Weight:345.14
Yield:1591828-80-6 700 mg
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 4 h;Inert atmosphere;
Steps:
160.3
A mixture of 5-bromo-6-(difluoromethyl)pyrimidin-4(3H)-one (1.01 g, 4.49 mmol), PMBC1 (735 mg, 4.71 mmol), potassium carbonate (1.24 g, 8.98 mmol) in DMF (10 mL) was stirred at r.t for 4 hr under nitrogen atmosphere. 15 mL of water was added and the precipitate was collected by filtration to give 5-bromo-6-(difluoromethyl)-3- (4-methoxybenzyl) pyrimidin-4(3H)-one (700 mg). MS (ESI): m/z 345, 347 (M+H) +
References:
WO2014/58747,2014,A1 Location in patent:Page/Page column 197
677777-60-5
3 suppliers
inquiry
1591828-80-6
0 suppliers
inquiry