ChemicalBook CAS DataBase List 16-HEXADECANOLIDE

16-HEXADECANOLIDE synthesis

10synthesis methods

Product Name:16-HEXADECANOLIDE
CAS Number:109-29-5
Molecular formula:C16H30O2
Molecular Weight:254.41

By the persulphuric acid (or other peracid) oxidation of cyclohexadecanone.

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109-29-5
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Yield:109-29-5 99 %Chromat.

Reaction Conditions:

with 5%-palladium/activated carbon;hydrogen in methanol at 25; for 3 h;

Steps:

10
In a 50mL two-necked flask, to which a pressure-resistant balloon filled with hydrogen gas was attached, 1.0 g of oxacycloheptadec-10-en-2-one (IV-2) (with a purity of 100%, 4.0 mmol) and 20 mg of Pd/C catalyst (5% Wet) were placed and then were dissolved in10 mL of methanol. The inside of the flask was subjected to pressure reduction with a vacuum line and then to hydrogen substitution. This was stirred at room temperature (25 degrees C) for three hours. The liquid obtained after completion of the reaction was subjected to gas chromatography quantitative analysis. As a result, it contained 0.99 g of oxacycloheptadecan-2-one (V-2) (3.9 mmol, yield 99.0%).

References:

KAO CORPORATION;NAKAZAWA, Yuki;AOKI, Takashi WO2016/103677, 2016, A1 Location in patent:Paragraph 0125

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