5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-4-chloro-2-nitro-benzeneacetic Acid synthesis
- Product Name:5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-4-chloro-2-nitro-benzeneacetic Acid
- CAS Number:160384-40-7
- Molecular formula:C21H21ClN4O4S
- Molecular Weight:460.93
19398-61-9
136 suppliers
$10.00/5G
160384-40-7
12 suppliers
inquiry
Yield:-
Steps:
Multi-step reaction with 6 steps
1: 56 percent / conc. H2SO4, HNO3 / acetic acid / 2 h / Ambient temperature
2: 58 percent / tetrahydrofuran / 8 h / Heating
3: 93 percent / acetic acid / Ambient temperature
4: 71 percent / acetic acid, sodium triacetoxyborohydride / 1,2-dichloro-ethane
5: 82.5 percent / potassium hydroxide / various solvent(s) / 4 h / 57 °C / solvent: N-methyl-pyrrolidinone
6: aq. HCl
References:
Urban, Frank J.;Breitenbach, Ralph;Gonyaw, Dianne [Synthetic Communications,1996,vol. 26,# 8,p. 1629 - 1638]
![2-[5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-4-chloro-2-nitrophenyl]-propanedioic Acid 1,3-DiMethyl Ester](/CAS/GIF/160384-39-4.gif)
160384-39-4
12 suppliers
inquiry
160384-40-7
12 suppliers
inquiry
7149-76-0
13 suppliers
$28.60/50MG
160384-40-7
12 suppliers
inquiry
![3-[4-[2-(2,5-Dichloro-4-nitrophenyl)ethyl]-1-piperazinyl]-1,2-benzisothiazole](/CAS/GIF/160384-38-3.gif)
160384-38-3
12 suppliers
inquiry
160384-40-7
12 suppliers
inquiry