ChemicalBook CAS DataBase List 1,4-DICHLORO-2-METHYL-5-NITRO-BENZENE

1,4-DICHLORO-2-METHYL-5-NITRO-BENZENE synthesis

8synthesis methods

Product Name:1,4-DICHLORO-2-METHYL-5-NITRO-BENZENE
CAS Number:7149-76-0
Molecular formula:C7H5Cl2NO2
Molecular Weight:206.03

19398-61-9 Synthesis

19398-61-9
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7149-76-0
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$28.60/50MG

Yield:7149-76-0 90%

Reaction Conditions:

with HNO₃ in 1,2-dichloro-ethane at 30 - 35; for 2 h;Solvent;

Steps:

8-12 Example 8: Preparation method of dichlorotoluene nitrate intermediate (preparation of 2,5-dichloro-4-nitrotoluene),The difference from Example 1 is that it is prepared through the following steps:

Step 1. Dissolve 32.2g (0.2mol) of 2,5-dichlorotoluene in 100g of dichloroethane in a three-necked flask,Slowly add 13.9g (0.22mol) of 98% nitric acid at 30°C and keep the temperature of the reaction system not exceeding 35°C.After the dropwise addition, the reflux reaction was completed for 2.0 h, monitored by TLC, and after the reaction was completed, a dichloroethane solution of 2,5-dichloro-4-nitrotoluene was obtained.Step 2: Add a saturated sodium bicarbonate aqueous solution to the above solution for cleaning and neutralization, and dichloroethane is distilled out.After cooling and crystallizing and drying, 37.1 g of light yellow solid: 2,5-dichloro-4-nitrotoluene was obtained, and the yield was 90%.

References:

CN112266326,2021,A Location in patent:Sheet 0050-0052; 0054-0057; 0065