methyl 2-aminoH-pyrazolo[1,5-a]pyridine-3-carboxylate hydrochloride synthesis
- Product Name:methyl 2-aminoH-pyrazolo[1,5-a]pyridine-3-carboxylate hydrochloride
- CAS Number:1620075-73-1
- Molecular formula:C9H9N3O2
- Molecular Weight:191.19
![Pyrazolo[1,5-a]pyridine-3-carbonitrile, 2-amino-](/CAS/GIF/864365-51-5.gif)
Yield: 45.1%
Reaction Conditions:
with hydrogenchloride at 80; for 24 h;
Steps:
31; XXXIX Example 31
A mixture of XXXIX-2 (1.1 g, 6.96 mmol) in HCl/MeOH (4N, 20 mL) was stirred at 80° C. for 24 h. After concentrated, the mixture was diluted with EtOAc, washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by column (PE/EA=2/1) to afford XXXIX-3 (600 mg, yield 45.1%).
References:
Buckman, Brad Owen;Nicholas, John Beamond;Emayan, Kumaraswamy;Seiwert, Scott D. US2014/200215, 2014, A1 Location in patent:Paragraph 1258; 1260
![methyl 2-(tert-butoxycarbonyl)H-pyrazolo[1,5-a]pyridine-3-carboxylate](/CAS/20200611/GIF/1476799-73-1.gif)
1476799-73-1
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1620075-73-1
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