ChemicalBook CAS DataBase List 3-Benzenediol, 4-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-1

3-Benzenediol, 4-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-1 synthesis

5synthesis methods

Product Name:3-Benzenediol, 4-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-1
CAS Number:1668-53-7
Molecular formula:C25H23N3O2
Molecular Weight:397.47

2-chloro-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine

1237-53-2

108-46-3

3-Benzenediol, 4-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-1

1668-53-7

The general procedure for the synthesis of 4-(4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)benzene-1,3-diol from 2-chloro-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)benzene-1,3-diol using 2-chloro-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl and resorcinol was carried out as follows: in a 50 mL three-necked flask protected by a dry nitrogen gas, 2-chloro-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-1,3,5-triazin-2-yl (1.6 mmol) and 2-chloro-4,6 -bis(2,4-dimethylphenyl)-1,3,5-triazine (1.6 mmol) and anhydrous aluminum trichloride (0.32 g, 2.4 mmol) to anhydrous chlorobenzene (15 mL), and the reaction mixture was stirred for 0.5 hours at 25 °C. Subsequently, resorcinol (0.24 g, 2.2 mmol) was added and the reaction mixture was warmed up to 85 °C for continued stirring for 5 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction was quenched by the slow addition of ice water (10 mL), followed by evaporation under reduced pressure to remove the chlorobenzene. The mixture was filtered and the resulting solid was washed with water (3 x 10 mL) and finally recrystallized from ethyl acetate to afford the target product 4-(4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)benzene-1,3-diol and its derivatives.