(S)-1-benzyl 5-methyl 2-oxoimidazolidine-1,5-dicarboxylate synthesis
- Product Name:(S)-1-benzyl 5-methyl 2-oxoimidazolidine-1,5-dicarboxylate
- CAS Number:168399-08-4
- Molecular formula:C13H14N2O5
- Molecular Weight:278.26
4668-37-5
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Yield:168399-08-4 87%
Reaction Conditions:
Stage #1: N-(benzyloxycarbonyl)asparagine methyl esterwith [bis(acetoxy)iodo]benzene;1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran at 0; for 0.25 h;Inert atmosphere;Hofmann rearrangement;
Stage #2: with water in tetrahydrofuran at 0 - 20; for 0.5 h;Inert atmosphere;Hofmann rearrangement;
References:
Angelici, Gaetano;Contaldi, Simone;Lynn Green, Sarah;Tomasini, Claudia [Organic and Biomolecular Chemistry,2008,vol. 6,# 10,p. 1849 - 1852] Location in patent:experimental part
2304-96-3
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501-53-1
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168399-08-4
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