4-(5-amino-1,3,4-oxadiazol-2-yl)phenol(SALTDATA: FREE) synthesis
- Product Name:4-(5-amino-1,3,4-oxadiazol-2-yl)phenol(SALTDATA: FREE)
- CAS Number:1750-79-4
- Molecular formula:C8H7N3O2
- Molecular Weight:177.16
![Hydrazinecarboxamide,2-[(4-hydroxyphenyl)methylene]-](/CAS/20180529/GIF/58336-40-6.gif)
58336-40-6
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1750-79-4
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$133.00/5 g
Yield: 93%
Reaction Conditions:
with pyridine;manganese(IV) oxide at 120;Green chemistry;
Steps:
13 2-amino-5-(4'-hydroxyphenyl)-1,3,4-oxadiazole
To a dry threeneckedflask Amol 2(4'hydroxyphenyl)methylene semicarbazide, Bmol CmL manganese dioxide andpyridine at 120 ° C under stirring reaction, the reaction was monitored by TLC reaction Until aminals urea feed pointdisappears, to obtain a reaction mixture wherein, A: B: C = 1: 1.1: 8 TLC monitoring When measuring the eluent used is amixture of ethyl acetate and petroleum ether made, and ethyl acetate and petroleum ether The volume ratio of 1: 5[2]2)The reaction mixture was cooled to room temperature, vacuum filtration, and the filtrate was concentrated to dryness togive, as a white solid Body, a white solid was washed with water, vacuum filtration to give the crude product, the crudeproduct was recrystallized from anhydrous ethanol 2Amino5(4'hydroxyphenyl)1,3,4oxadiazolepure, yield of 93%.
References:
Shaanxi University of Science and Technology;YIN, DA WEI;ZHANG, XIAO LI;LIU, SEN;QIAO, SEN;ZHAO, BIN JIE;YANG, AN NING;WANG, JIN YU;LU, BO CN103980222, 2016, B Location in patent:Paragraph 0065-0067
58975-53-4
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1518-16-7
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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1000210-73-0
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1750-79-4
17 suppliers
$133.00/5 g
123-08-0
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1750-79-4
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506-68-3
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5351-23-5
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1750-79-4
17 suppliers
$133.00/5 g