3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:3-FORMYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:177947-96-5
- Molecular formula:C9H15NO3
- Molecular Weight:185.22
142253-56-3
255 suppliers
$6.00/1g
177947-96-5
174 suppliers
$11.00/100mg
Yield:177947-96-5 99%
Reaction Conditions:
with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetateReflux;
Steps:
1 tert-butyl 3-formylazetidine-1-carboxylate (1.3)
To a stirringsolutionof tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate(20.96 g, 112 mmol) in EA (500 ml)was added IBX (62.69 g, 224 mmol) and the reaction was refluxed overnight. The reaction was cooledto rt, PE (500 ml)was added and the reaction mixture was filtered. The filtrate was concentrated under reduced pressureto give compound1.3 as yellow oil product (20.56 g,99%). 1H NMR (400 MHz, CDCI3) i5 1.44 (s, 9 H), 3.32-3.4015 (m, 1 H), 4.07-4.14 (m, 4 H), 9.85 (d, J = 2.0Hz, 3 H).
References:
ACHAOGEN, INC.;LINSELL, Martin Sheringham;AGGEN, James Bradley;DOZZO, Paola;HILDEBRANDT, Darin James;COHEN, Frederick;KASAR, Ramesh Annasaheb;KANE, Timothy Robert;GLIEDT, Micah James;MCENROE, Glenn A. WO2014/165075, 2014, A1 Location in patent:Page/Page column 45; 46
610791-05-4
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177947-96-5
174 suppliers
$11.00/100mg
142253-54-1
178 suppliers
$9.00/250mg
177947-96-5
174 suppliers
$11.00/100mg
398489-26-4
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$9.00/5g
4009-98-7
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$5.00/10g
177947-96-5
174 suppliers
$11.00/100mg
142253-56-3
255 suppliers
$6.00/1g
177947-96-5
174 suppliers
$11.00/100mg