Carbamic acid, (3-fluoropropyl)-, 1,1-dimethylethyl ester (9CI) synthesis
- Product Name:Carbamic acid, (3-fluoropropyl)-, 1,1-dimethylethyl ester (9CI)
- CAS Number:178181-51-6
- Molecular formula:C8H16FNO2
- Molecular Weight:177.22
64068-31-1
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Yield: 100%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 16 h;
Steps:
208.A
3-Fluoropropan-l -amine hydrochloride (1.00 g, 8.81 mmol) was dissolved in 90 mis of dry dichloro methane. To this was added di-t-butyl dicarbonate (2.11 g, 9.69 mmol) and triethylamine (2.70 mis, 19.37 mmol). This mixture was stirred at room temperature for 16 hours, then washed with IN aq. HCl (1 X), saturated sodium bicarbonate solution (IX), dried over sodium sulfate and concentrated under reduced pressure to give 1.6 g (100%) of tert-butyl 3- fluoropropylcarbamate as a clear and colorless oil.
References:
VENTIRX PHARMACEUTICALS, INC.;ARRAY BIOPHARMA, INC;HOWBERT, James, Jeffry;DIETSCH, Gregory;HERSHBERG, Robert;BURGESS, Laurence, E.;DOHERTY, George, A.;EARY, C. Todd;GRONEBERG, Robert, D.;JONES, Zachary WO2011/22509, 2011, A2 Location in patent:Page/Page column 99
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