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2'-O-(tert-Butyldimethylsilyl)-N-isobutyrylguanosine synthesis

8synthesis methods
81279-39-2 Synthesis
N2-Isobutyryl-2''-O-(tert-butyldimethylsilyl)-5''-O-(4,4''-dimethoxytrityl)-gu

81279-39-2
91 suppliers
$27.00/250mg

2'-O-(tert-Butyldimethylsilyl)-N-isobutyrylguanosine

182007-86-9
26 suppliers
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Yield:182007-86-9 92%

Reaction Conditions:

with dichloro-acetic acid in dichloromethane at 20; for 0.25 h;

References:

Wexselblatt, Ezequiel;Katzhendler, Jehoshua;Saleem-Batcha, Raspudin;Hansen, Guido;Hilgenfeld, Rolf;Glaser, Gad;Vidavski, Roee R. [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 12,p. 4485 - 4497] Location in patent:experimental part