Ethanone, 2-fluoro-1-[4-(trifluoromethyl)phenyl]- (9CI) synthesis
- Product Name:Ethanone, 2-fluoro-1-[4-(trifluoromethyl)phenyl]- (9CI)
- CAS Number:186297-56-3
- Molecular formula:C9H6F4O
- Molecular Weight:206.14
Yield:186297-56-3 75%
Reaction Conditions:
Stage #1: fluoroiodomethanewith methyllithium in tetrahydrofuran;diethyl ether at -60; for 3.61111E-06 h;Flow reactor;
Stage #2: N-methoxy-N-methyl-4-trifluoromethylbenzamide in tetrahydrofuran;diethyl ether at -60; for 0.00218056 h;Flow reactor;chemoselective reaction;
References:
Colella, Marco;Degennaro, Leonardo;Higuma, Ryosuke;Ishikawa, Susumu;Luisi, Renzo;Nagaki, Aiichiro;Takahashi, Yusuke;Tota, Arianna [Angewandte Chemie - International Edition,2020,vol. 59,# 27,p. 10924 - 10928][Angew. Chem.,2020,vol. 132,# 27,p. 11016 - 11020,5] Location in patent:supporting information
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![Ethanone, 2-chloro-1-[4-(trifluoromethyl)phenyl]-](/CAS/20200611/GIF/95727-89-2.gif)