4-(2-Hydroxyethyl)-4-azatricyclo-[5.2.1.06]dec-8-ene-3,5-dione synthesis
1synthesis methods
- Product Name:4-(2-Hydroxyethyl)-4-azatricyclo-[5.2.1.06]dec-8-ene-3,5-dione
- CAS Number:1873-11-6
- Molecular formula:C11H13NO3
- Molecular Weight:207.23
Yield:1873-11-6 143.0 g
Reaction Conditions:
in toluene at 30 - 120;
Steps:
39
Nadic anhydride (164.2 g, 1.00 mole) was dissolved in 220 ml of toluene. To the mixture was slowly added ethanolamine (61.1 g, 1.00 mole) at 30-70° C. and then stirred for 7 hours at 100-120° C. to remove water and part of toluene. Afier overnight in room temperature the resulting yellow crystal was filtered and dried to obtain 143.0 g of nadic imide. 1HNMR(DMSO) 1.50(m, 1H), 1.78(m, 1H),3.08(s, 1H), 3.35 (m, 2H), 3.46 (m, 2H), 3.59 (m, 2H), 3.68 (m, 2H), 6.16 (d, 2H).
References:
US2013/317156,2013,A1 Location in patent:Paragraph 0229