2-Azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2-(1,1-diMethylethyl) 3-ethyl ester, (1R,3S,4S)- synthesis
- Product Name:2-Azabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, 2-(1,1-diMethylethyl) 3-ethyl ester, (1R,3S,4S)-
- CAS Number:188057-42-3
- Molecular formula:C14H23NO4
- Molecular Weight:269.34
![2-Azabicyclo[2.2.1]heptane-3-carboxylicacid,ethylester,(1R,3S,4S)-(9CI)](/CAS/GIF/214910-41-5.gif)
Yield:188057-42-3 95%
Reaction Conditions:
with triethylamine in tetrahydrofuran;water at 20; for 40 h;
Steps:
5
Step5: To R5G in a solution of triethylamin (24.6 ml), THF (150 ml) and water (2ml), R5I (15.9 g; 73 mmol) is added and the resulting mixture stirred for 40hours at room temperature, then concentrated in vacuo. Ethyl acetate is added to the residue, subsequently extracted with water, 1 N acidic acid and water, before the organic layer is dired over MgS04 and concentrated in vacuo to yield R5I. (Yield 95% m/z 270 [M+H]+, rt 1.33 min, LC-MS Method V003_003).
References:
WO2014/140075,2014,A1 Location in patent:Page/Page column 198-200
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134984-63-7
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![ethyl (1R,3S,4S)-2-[(1R)-1-phenylethyl]-2-azabicyclo[2.2.1]heptane-3-carboxylate](/CAS/20200401/GIF/192461-70-4.gif)
192461-70-4
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