Methyl 3-amino-7-methoxybenzo[b]thiophene-2-carboxylate synthesis
- Product Name:Methyl 3-amino-7-methoxybenzo[b]thiophene-2-carboxylate
- CAS Number:198204-08-9
- Molecular formula:C11H11NO3S
- Molecular Weight:237.27
2365-48-2
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198203-94-0
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198204-08-9
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Yield:198204-08-9 94%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 1.5 h;Inert atmosphere;
Steps:
A.A.1.A.1.12.A.1.12.7 A.1.12.7. Methyl 3-amino-7-methoxybenzo[b]thiophene-2-carboxylate
To a mixture of 2-fluoro-3-methoxybenzonitrile (7.000 g, 45.90 mmol) and potassium carbonate (12.802 g, 91.70 mmol) in DMF (50 mL) is added dropwise methyl 2-mercaptoacetate (4.53 mL, 48.10 mmol). The RM is stirred at RT, under nitrogen, for 1.5h. Water is then added, and the resulting suspension is filtered. The separated solid is then washed with water and dried under high vacuum to give methyl 3-amino-7- methoxybenzo[b]thiophene-2-carboxylate as a beige solid (10.200 g, 94%). LC-MS B: tR = 0.90 min; [M+H]+ = 238.07.
References:
WO2018/210987,2018,A1 Location in patent:Page/Page column 87
142596-50-7
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2365-48-2
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$14.00/25g
198204-08-9
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137654-20-7
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198204-08-9
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198204-64-7
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198204-08-9
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