ChemicalBook CAS DataBase List 1H-Imidazole, 2-(trifluoromethyl)-

1H-Imidazole, 2-(trifluoromethyl)- synthesis

7synthesis methods

Product Name:1H-Imidazole, 2-(trifluoromethyl)-
CAS Number:66675-22-7
Molecular formula:C4H3F3N2
Molecular Weight:136.08

131543-46-9

421-53-4

66675-22-7

General procedure for the synthesis of 2-(trifluoromethyl)-1H-imidazole from the compound (CAS:131543-46-9) and 2,2,2-trifluoroethane-1,1-diol: 20 mL of ammonia aqueous solution was added to a three-necked flask at room temperature and stirred. Subsequently, 5 mL of trifluoroacetaldehyde hydrate was mixed with 5 mL of glyoxal and slowly added dropwise to the aqueous ammonia solution, and the reaction was carried out for 2 hours at room temperature. After the reaction was completed, 20 mL of ethyl acetate was added for extraction for 30 minutes. The ethyl acetate layer was separated and dried with anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give a final 4.2 g of brown oily product, 2-(trifluoromethyl)-1H-imidazole.

131543-46-9 Synthesis

131543-46-9
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421-53-4 Synthesis

421-53-4
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$15.00/1g

66675-22-7
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$35.00/250mg

Yield:66675-22-7 4.2 g

Reaction Conditions:

with ammonium hydroxide at 20; for 2 h;Reagent/catalyst;

Steps:

1 Example 1: Preparation of 2-trifluoromethyl imidazole
20ml of ammonia solution was added into a three-necked flask and stirred at room temperature. Then 5ml of trifluoroacetaldehyde hydrate and 5ml of glyoxal were mixed and slowly added dropwise to ammonia water for reaction at room temperature for 2 hours.After the reaction was completed, 20 ml of ethyl acetate was added to extract for 30 min. The ethyl acetate layer was separated and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to give 4.2 g of a brown oil, that is, 2-trifluoromethylimidazole.

References:

Shanxi Synthetic Pharmaceutical Co., Ltd.;Jiangsu Tiandi Renhe Pharmaceutical Co., Ltd.;Lu Hualong;Zhang Qiyuan CN107365272, 2017, A Location in patent:Paragraph 0018; 0019

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131543-46-9 Synthesis

131543-46-9
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