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17450-61-2

1H-Indene-4-methanamine, 2,3-dihydro-N-methyl- synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere
2: sodium hydroxide / tetrahydrofuran / 1 h / 0 - 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

References:

Wang, Youxin;Di, Hongxia;Chen, Feifei;Xu, Yong;Xiao, Qiang;Wang, Xuehai;Wei, Hanwen;Lu, Yanli;Zhang, Lingling;Zhu, Jin;Lan, Lefu;Li, Jian [Journal of Medicinal Chemistry,2016,vol. 59,# 10,p. 4831 - 4848]