(1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER synthesis
- Product Name:(1H-INDOL-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS Number:819850-13-0
- Molecular formula:C13H16N2O2
- Molecular Weight:232.28
5192-23-4
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24424-99-5
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819850-13-0
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Yield:819850-13-0 28.5%
Reaction Conditions:
with triethylamine in dichloromethane at 0; for 13 h;
Steps:
52.1 Step 1’) tert-butyl 1H-indol-4-ylcarbamate
[00354] To dichloromethane (20 mL) were added 4-aminoindole (2.0 g, 15.1 mmol) and triethylamine (6.0 mL, 43 mmol) at 0 °C, then Boc2O (4.5 mL, 20 mmol) was added dropwise. The mixuture was sitirred for 13 hours, then concentrated in vacuo and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as a gray solid (998 mg, 28.5%). The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 233.2 [M+Hfb; and ‘HNIVIR (600 MHz, DMSO-d6) (ppm): 11.01 (s, 1H), 8.95 (s, 1H), 7.34 (d, J= 7.5 Hz, 1H), 7.21 (t, J= 2.8 Hz, 1H), 7.07 (d, J 8.1 Hz, 1H), 6.97 (t, J= 7.9 Hz, 1H), 6.73 (t, J= 2.1 Hz, 1H), 1.50 (s, 9H).
References:
WO2016/4882,2016,A1 Location in patent:Paragraph 00354
1380445-23-7
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819850-13-0
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53324-38-2
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819850-13-0
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$50.00/500mg
24424-99-5
860 suppliers
$13.50/25G
819850-13-0
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$50.00/500mg
1380445-22-6
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819850-13-0
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