1H-Indol-5-amine, 7-fluoro- synthesis
- Product Name:1H-Indol-5-amine, 7-fluoro-
- CAS Number:926028-84-4
- Molecular formula:C8H7FN2
- Molecular Weight:150.15
1167055-33-5
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926028-84-4
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Yield:926028-84-4 200 mg
Reaction Conditions:
with iron;ammonium chloride in water;ethyl acetate at 60; for 4 h;
Steps:
78.f (f) 7-Fluoro-1 H-indol-5-amine
To a stirred solution of 7-fluoro-5-nitro-1 /-/-indole (300 mg) in EtOAc (15 ml_) and water (15 ml_) was added iron (465 mg) followed by ammonium chloride (356 mg). The reaction mixture was heated to 60 °C and stirred for 4 hr. The reaction mixture was filtered through Celite and extracted with EtOAc (20 ml_). The EtOAc extract was dried over sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound (200 mg). GCMS m/z 150.1 (M+).
References:
WO2017/153952,2017,A1 Location in patent:Page/Page column 154
926028-83-3
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769966-04-3
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1268816-57-4
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387-44-0
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926028-84-4
38 suppliers
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