7-Fluoroindole synthesis
- Product Name:7-Fluoroindole
- CAS Number:387-44-0
- Molecular formula:C8H6FN
- Molecular Weight:135.14
317-20-4
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$6.00/1g
387-44-0
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$24.00/1g
Yield:387-44-0 78.8%
Reaction Conditions:
with sodium tetrahydroborate;boron trifluoride diethyl etherate in tetrahydrofuran at -10 - -5;Inert atmosphere;
Steps:
1 Example 1
Under nitrogen protection,4 g (0.024 mol) of 7-fluoro isatinAnd 3.52 g (0.093 mol) of sodium borohydride were put into a dry four-necked flask,Cooled to -10 ° C or less,Stirring,To this, 40 mL of dry tetrahydrofuran was slowly added dropwiseAnd 7.6 g (0.054 mol) of borontrifluoride etherate,The whole process control temperature does not exceed -5 ,Reaction overnight,Reaction completed,A solution of 6.6 g of sodium hydrogen sulfate and 70 mL of water was slowly added dropwise to the solution,Steam distillation mixture,The distillate was extracted with ethyl acetate,Dried over anhydrous magnesium sulfate,The solvent was distilled off,To give 2.58 g of white needles (yield 78.8%).
References:
CN105732462,2016,A Location in patent:Paragraph 0016; 0019
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317 suppliers
$24.00/1g