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83894-17-1

1H-Indole-3-carbonyl chloride, 2-chloro- (9CI) synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 78 percent / 2-methyl-2-butene, aq. NaClO2, NaH2PO4 / dioxane / 6.5 h
2: SOCl2 / 1,2-dichloro-ethane / 2 h / 75 °C

References:

Showalter, H. D. Hollis;Sercel, Anthony D.;Leja, Boguslawa M.;Wolfangel, Craig D.;Ambroso, Linda A.;Elliott, William L.;Fry, David W.;Kraker, Alan J.;Howard, Curtis T.;Lu, Gina H.;Moore, Charles W.;Nelson, James M.;Roberts, Bill J.;Vincent, Patrick W.;Denny, William A.;Thompson, Andrew M. [Journal of Medicinal Chemistry,1997,vol. 40,# 4,p. 413 - 426]