1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester synthesis
- Product Name:1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester
- CAS Number:82231-59-2
- Molecular formula:C7H9IN2O2
- Molecular Weight:280.06
3469-69-0
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Yield:82231-59-2 81%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
20.1 The first step: 2-(4-iodopyrazole-1-yl) ethyl acetate (20a)
The compound 4-iodo-1H-pyrazole (3g, 15.5mmol) was dissolved in 30mL DMF,Add 2-chloroethyl acetate (1.9 g, 15.5 mmol) and cesium carbonate (10.1 g, 30.9 mmol) in sequence, and stir at room temperature for 2 h.Add 50mL water and 50mL ethyl acetate for extraction, and then wash the organic layer 4 times with 50mL saturated brine.After concentration under reduced pressure, the target product was obtained as a yellow oil (3.5 g, 81% yield).
References:
CN112010858,2020,A Location in patent:Paragraph 1001-1009
