ChemicalBook CAS DataBase List 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID synthesis

7synthesis methods

Product Name:1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
CAS Number:952182-02-4
Molecular formula:C7H5N3O2
Molecular Weight:163.13

1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 1-[(4-methoxyphenyl)methyl]-, ethyl ester

1086423-59-7
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1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

952182-02-4
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Yield: 80%

Reaction Conditions:

with trifluoroacetic acid at 80; for 4 h;

Steps:

4.5 Intermediate 4: 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid
Step 5. Ethyl 1-(4-methoxybenzyl )-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (4.4 g, 1 4 mmol) was dissolved in TFA (1 58 mL) and heated to 80 °C. The mixture was stirred at 80 "C for 4 h, then was concentrated to dryness. The residue was poured into ice water, then aqueous NaOH solution (2 M) was added until the pH was approximately 14 The solid formed was removed by filtration, and the aqueous layer was washed with ethyl acetate. To the aqueous layer was added concentrated HCl was added until the pH was approximately 7. The resulting precipitate was collected by vacuum filtration and dried under vacuum to afford the title compound as a white solid (2. 1 g, 80%). 1H NMR (400 MHz, DMSO-d6) δ 1 4.38- 13 62 (br, 1 H), 9.07 (d, J = 1 .6 Hz, 1 H), 8.81 (d, J = 1 .6 Hz, 1 H), 8.32 (s, 1 H). MS (m/z, ESI+): 1 64 [M+H]

References:

Location in patent:Page/Page column 131; 133

1196156-42-9 Synthesis