1H-TETRAZOLE, 1-(3-BROMOPHENYL)- synthesis
- Product Name:1H-TETRAZOLE, 1-(3-BROMOPHENYL)-
- CAS Number:65697-41-8
- Molecular formula:C7H5BrN4
- Molecular Weight:225.05
122-51-0
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591-19-5
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65697-41-8
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$45.00/25mg
Yield:65697-41-8 91%
Reaction Conditions:
with sodium azide;bis(trifluoromethanesulfonyl)amide in glycerol at 20; for 3 h;Green chemistry;
Steps:
Synthesis of 1-substituted-1H-1,2,3,4-tetrazoles (2a-o); general procedure
General procedure: A mixture of amine (2 mmol), sodium azide (2 mmol), triethylorthoformate (2.4 mmol), glycerol (8 mL) and HNTf2 (5 mol%) wastaken in a round bottomed flask and stirred at room temperature. Theprogress of the reaction was monitored by TLC. After completion, thereaction mixture was diluted with cold water (5 mL) and extracted witha mixture of hexane/ethyl acetate 95:5 (3 × 10 mL). The combinedorganic layers were washed with brine and dried over anhydrousNa2SO4. The residue was concentrated and recrystallised from ethylacetate/hexane 2:1 to afford the pure product.
References:
Wang, Hongshe;Wei, Fenyan;Chen, Qi;Hu, Xiaobing;Niu, Xiaomei [Journal of Chemical Research,2016,vol. 40,# 9,p. 570 - 572]
591-19-5
334 suppliers
$10.00/10g
149-73-5
547 suppliers
$12.00/5g
65697-41-8
16 suppliers
$45.00/25mg