(1R)-1-(5-FLUORO(2-PYRIDYL))ETHYLAMINE synthesis

Yield:99 % ee

Reaction Conditions:

with glucose dehydrogenase;ammonium hydroxide;galactose;amine dehydrogenase from Jeotgalicoccus aerolatus K₆₇S/N₂₆₀L/E₁₁₃V/V₂₉₁G mutant;ammonia hydrochloride in dimethyl sulfoxide at 30; pH=9.5; for 48 h;Enzymatic reaction;enantioselective reaction;

References:

Gao, Jing;Huang, Chen;Jiang, Yanjun;Kong, Weixi;Liu, Yunting;Turner, Nicholas J.;Zhou, Liya [Angewandte Chemie - International Edition,2022,vol. 61,# 21,art. no. E202202264][Angew. Chem.,2022,vol. 134,# 21] Location in patent:supporting information