(1S,2S)-trans-N-Boc-2-aminocyclopentanol synthesis
- Product Name:(1S,2S)-trans-N-Boc-2-aminocyclopentanol
- CAS Number:145106-43-0
- Molecular formula:C10H19NO3
- Molecular Weight:201.26
24424-99-5
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145106-43-0
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Yield: 97.76%
Reaction Conditions:
with triethylamine in methanol for 22 h;
Steps:
L.1
Step 1. To a solution of (lS,2S)-2-aminocyclopentan-l-ol (41-1) HC1 salt (500.00 mg, 3.63 mmol) and triethylamine (1.10 g, 10.89 mmol, 1.51 mL) in MeOH (18.15 mL) was added Boc20 (1.58 g, 7.26 mmol). The reaction was stirred for 22 hour, concentrated under reduced pressure. Flash chromatography (ISCO system, silica (24 g), 0-50% ethyl acetate in hexane) provide 41-2 (714.2 mg, 3.55 mmol, 97.76% yield).
References:
TP THERAPEUTICS, INC.;CUI, Jingrong J.;LI, Yishan;ROGERS, Evan W.;ZHAI, Dayong;DENG, Wei;UNG, Jane WO2017/4342, 2017, A1 Location in patent:Paragraph 0528
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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145106-43-0
67 suppliers
$65.00/100mg
1000210-73-0
0 suppliers
inquiry
145106-43-0
67 suppliers
$65.00/100mg
24424-99-5
868 suppliers
$13.50/25G
1000210-73-0
0 suppliers
inquiry
145106-43-0
67 suppliers
$65.00/100mg
24424-99-5
868 suppliers
$13.50/25G
145106-43-0
67 suppliers
$65.00/100mg